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Flex-nucleoside analogues - Novel therapeutics against filoviruses.
Yates, Mary K; Raje, Mithun R; Chatterjee, Payel; Spiropoulou, Christina F; Bavari, Sina; Flint, Mike; Soloveva, Veronica; Seley-Radtke, Katherine L.
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  • Yates MK; Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, United States.
  • Raje MR; Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, United States.
  • Chatterjee P; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States.
  • Spiropoulou CF; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States.
  • Bavari S; US Army Medical Research Institute, Frederick, MD 21702, United States.
  • Flint M; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States.
  • Soloveva V; US Army Medical Research Institute, Frederick, MD 21702, United States.
  • Seley-Radtke KL; Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, United States. Electronic address: kseley@umbc.edu.
Bioorg Med Chem Lett ; 27(12): 2800-2802, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28465098
ABSTRACT
Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC50=2µM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC50 of 7µM.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Ebolavirus / Nucleósidos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Ebolavirus / Nucleósidos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos