Geldanamycin inhibits Fas signaling pathway and protects neurons against ischemia.
Neurosci Res
; 124: 33-39, 2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-28522336
ABSTRACT
The inhibitor of Heat shock proteins 90, geldanamycin (GA), has been reported neuroprotective against both global and focal brain ischemia. To understand the mechanisms underlies the neuroprotection effect of GA, we investigated the relationship between GA pretreatment and Fas signaling pathway in rat global brain ischemia/reperfusion model in the present study. Results showed that GA attenuated neuron loss significantly in hippocampal CA1 region. Upon GA pretreatment, Mixed Lineage Kinase 3 (MLK3) expression and activation and FasL expression was decreased, the assembly of death-inducing signaling complex and activation of downstream apoptosis-associating proteins were inhibited along with neuroprotection. Based on the facts that MLK3 is one client protein of HSP90 and MLK3 pathway induces FasL expression in ischemic brain injury, our study suggests one of the mechanisms of neuroprotection against brain ischemia from GA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Isquemia Encefálica
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Benzoquinonas
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Fármacos Neuroprotectores
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Lactamas Macrocíclicas
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Proteína Ligando Fas
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Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Neurosci Res
Asunto de la revista:
NEUROLOGIA
Año:
2017
Tipo del documento:
Article