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Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4+ Lymphopenia and Secondary Germline or Acquired Defects.
Panackal, Anil A; Rosen, Lindsey B; Uzel, Gulbu; Davis, Michael J; Hu, Guowu; Adeyemo, Adebowale; Tekola-Ayele, Fasil; Lisco, Andrea; Diachok, Christopher; Kim, Jonathan D; Shaw, Dawn; Sereti, Irini; Stoddard, Jennifer; Niemela, Julie; Rosenzweig, Sergio D; Bennett, John E; Williamson, Peter R.
Afiliación
  • Panackal AA; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Rosen LB; Division of Infectious Diseases, Department of Medicine, F. Hebert School of Medicine, Uniformed Services University of the Health Sciences.
  • Uzel G; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Davis MJ; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Hu G; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Adeyemo A; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Tekola-Ayele F; Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH.
  • Lisco A; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland.
  • Diachok C; Laboratory of Immunoregulation, DIR, NIAID, NIH.
  • Kim JD; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Shaw D; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
  • Sereti I; Leidos Biomedical Research, Inc., Frederick, Maryland.
  • Stoddard J; Laboratory of Immunoregulation, DIR, NIAID, NIH.
  • Niemela J; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland.
  • Rosenzweig SD; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland.
  • Bennett JE; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland.
  • Williamson PR; Laboratory of Clinical Infectious Diseases, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).
Open Forum Infect Dis ; 4(2): ofx082, 2017.
Article en En | MEDLINE | ID: mdl-28638843
ABSTRACT
Idiopathic CD4+ lymphopenia (ICL) predisposes to opportunistic infections (OIs) but can often remain asymptomatic and does not have a strong association with monogenic mutations. Likewise, cryptococcal meningoencephalitis, the most common OI in ICL, is not strongly associated with monogenic mutations. In this study, we describe 2 patients with ICL plus an additional immune defect one from an E57K genetic mutation in the nuclear factor-κß essential modulator, and the other with acquired autoantibodies to granulocyte-macrophage colony-stimulating factor. Thus, these cases may exemplify a "multi-hit model" in patients with ICL who acquire OIs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2017 Tipo del documento: Article