Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin.
Tissue Barriers
; 5(3): e1336194, 2017 07 03.
Article
en En
| MEDLINE
| ID: mdl-28650689
ABSTRACT
There are many types of biologic compartments in the body. Tight junctions (TJs) function to create a dynamic paracellular barrier to separate these compartments and maintain homeostasis. The TJ component claudin-1 is the major transmembrane protein responsible for forming the paracellular barrier in the epidermis; other claudins in the epidermis include claudin-3, -4, -12, -23 and -25. Accumulating evidence points to a relationship between claudin-1 and skin diseases; for example, a decrease in claudin-1 is reported in human atopic dermatitis. However, how claudin-1 directly or indirectly contributes to disease in the context of the paracellular barrier is poorly understood. We recently established several mouse lines in which the claudin-1 expression was systematically regulated, and showed that claudin-1 time- and dose-dependently regulates epidermis function and disease in vivo. In this commentary, we will discuss recent progress on this topic, including our latest findings, and remaining or newly arisen issues.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dermatitis Atópica
/
Eccema
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Tissue Barriers
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón