Use of axillary lymph node dissection (ALND) in patients with micrometastatic breast cancer.
J Surg Res
; 215: 55-59, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28688661
ABSTRACT
BACKGROUND:
Sentinel lymph node (SLN) biopsy is the current prognostic tool for clinically node-negative breast cancer patients. If the SLN reveals macrometastasis, axillary lymph node dissection (ALND) is recommended. However, the use of ALND in patients with micrometastasis is debated. The objective of this study was to assess the utilization of ALND in the treatment of micrometastatic breast cancer.METHODS:
An IRB approved, retrospective study of a pooled dataset of breast cancer patients with micrometastatic disease on SLN biopsy was performed. Patients diagnosed from 1999-2016 were identified via query of a single-institution National Comprehensive Cancer Network (NCCN) breast cancer database as well as a prospective tumor board.RESULTS:
A total of 91 patients were diagnosed with micrometastatic nodal disease. The median age at diagnosis was 56 y (range 31-85); median follow-up time was 47 mo (range 0-203 mo). 42/91(46.2%) patients had ALND of which 37/42 (88.1%) were a second operation; 3/42(7.1%) patients had additional positive nodes found at ALND. 44/91 (48.4%) patients received radiation. 7/91 (7.7%) patients had a recurrence, 5/7 local, including one axillary (2.1%; patient declined ALND).CONCLUSIONS:
Given that the risk of lymphedema after ALND ranges between 20%-53%, the morbidity of ALND may far exceed the likelihood of detecting further nodal involvement in women with micrometastatic disease 7.1% in this series.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pautas de la Práctica en Medicina
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Neoplasias de la Mama
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Carcinoma Lobular
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Carcinoma Ductal de Mama
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Micrometástasis de Neoplasia
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Escisión del Ganglio Linfático
Tipo de estudio:
Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Surg Res
Año:
2017
Tipo del documento:
Article