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Rituximab Restores IFN-γ-STAT1 Function and Ameliorates Disseminated Mycobacterium avium Infection in a Patient with Anti-Interferon-γ Autoantibody.
Koizumi, Yusuke; Sakagami, Takuro; Nishiyama, Naoya; Hirai, Jun; Hayashi, Yuta; Asai, Nobuhiro; Yamagishi, Yuka; Kato, Hideo; Hagihara, Mao; Sakanashi, Daisuke; Suematsu, Hiroyuki; Ogawa, Kenji; Mikamo, Hiroshige.
Afiliación
  • Koizumi Y; Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. ykoizumi@aichi-med-u.ac.jp.
  • Sakagami T; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan. ykoizumi@aichi-med-u.ac.jp.
  • Nishiyama N; Department of Respiratory Medicine and Infectious Disease, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
  • Hirai J; Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  • Hayashi Y; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan.
  • Asai N; Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  • Yamagishi Y; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan.
  • Kato H; Department of Respiratory Medicine, National Hospital Organization Higashinagoya Hospital, Nagoya, Aichi, Japan.
  • Hagihara M; Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  • Sakanashi D; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan.
  • Suematsu H; Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  • Ogawa K; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan.
  • Mikamo H; Department of Infection Control and Prevention, Aichi Medical University Hospital, Aichi, Japan.
J Clin Immunol ; 37(7): 644-649, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28779413
ABSTRACT
A 67-year-old Japanese female with back pain and severe cachexia visited our hospital. The diagnosis was disseminated Mycobacterium avium complex infection (dMAC) with multiple bone involvement. Anti-mycobacterial chemotherapy was started, but fever persisted and dislocation of cervical vertebrae has made her bedridden. Because anti-interferon (IFN)-γ autoantibody was positive, four doses of rituximab 375 mg/m2, every 7 day, were administered. Soon after treatment, progression of osteolytic lesions and wasting has stopped. We proved that rituximab has recovered IFN-γ signaling as shown by IFN-γ-induced STAT1 phosphorylation. It can be a promising option for dMAC cases with anti-IFN-γ autoantibody.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autoanticuerpos / Infección por Mycobacterium avium-intracellulare / Interferón gamma / Rituximab / Factores Inmunológicos Límite: Aged / Female / Humans Idioma: En Revista: J Clin Immunol Año: 2017 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autoanticuerpos / Infección por Mycobacterium avium-intracellulare / Interferón gamma / Rituximab / Factores Inmunológicos Límite: Aged / Female / Humans Idioma: En Revista: J Clin Immunol Año: 2017 Tipo del documento: Article País de afiliación: Japón