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Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.
Lay, Abigail C; Hurcombe, Jenny A; Betin, Virginie M S; Barrington, Fern; Rollason, Ruth; Ni, Lan; Gillam, Lawrence; Pearson, Grace M E; Østergaard, Mette V; Hamidi, Hellyeh; Lennon, Rachel; Welsh, Gavin I; Coward, Richard J M.
Afiliación
  • Lay AC; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Hurcombe JA; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Betin VMS; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Barrington F; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Rollason R; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Ni L; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Gillam L; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Pearson GME; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Østergaard MV; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
  • Hamidi H; Global Research, Novo Nordisk A/S, Måløv, Denmark.
  • Lennon R; Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Welsh GI; Wellcome Trust Centre for Cell-Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Coward RJM; Bristol Renal, Bristol Medical School, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
Diabetologia ; 60(11): 2299-2311, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28852804
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Receptor de Insulina / Podocitos / Insulina Límite: Animals / Humans / Male Idioma: En Revista: Diabetologia Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Receptor de Insulina / Podocitos / Insulina Límite: Animals / Humans / Male Idioma: En Revista: Diabetologia Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido