Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development.
Annu Rev Microbiol
; 71: 665-686, 2017 09 08.
Article
en En
| MEDLINE
| ID: mdl-28886683
ABSTRACT
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are emerging. Appropriate antimicrobial treatment and prevention, including effective vaccines, are urgently needed. To guide investigation, an experimental model of genital tract infection has been developed in female mice to study mechanisms by which Neisseria gonorrhoeae evades host-derived antimicrobial factors and to identify protective and immunosuppressive pathways. Refinements of the animal model have also improved its use as a surrogate host of human infection and accelerated the testing of novel therapeutic and prophylactic compounds against gonococcal infection. Reviewed herein are the (a) history of antibiotic usage and resistance against gonorrhea and the consequences of resistance mechanisms that may increase gonococcal fitness and therefore the potential for spread, (b) use of gonococcal infection in the animal model system to study mechanisms of pathogenesis and host defenses, and
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vacunas Bacterianas
/
Gonorrea
/
Farmacorresistencia Bacteriana
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Modelos Animales de Enfermedad
/
Antibacterianos
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Neisseria gonorrhoeae
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Annu Rev Microbiol
Año:
2017
Tipo del documento:
Article