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NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib.
Wolf, Christine; Garding, Angela; Filarsky, Katharina; Bahlo, Jasmin; Robrecht, Sandra; Becker, Natalia; Zucknick, Manuela; Rouhi, Arefeh; Weigel, Anja; Claus, Rainer; Weichenhan, Dieter; Eichhorst, Barbara; Fischer, Kirsten; Hallek, Michael; Kuchenbauer, Florian; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter; Mertens, Daniel.
Afiliación
  • Wolf C; Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Garding A; Signaling to Chromatin Laboratory, Institute of Molecular Biology, Mainz, Germany.
  • Filarsky K; Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bahlo J; Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Köln, Germany.
  • Robrecht S; Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Köln, Germany.
  • Becker N; Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Zucknick M; Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Rouhi A; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
  • Weigel A; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
  • Claus R; Department Medical Clinic II, Klinikum Augsburg, Augsburg, Germany.
  • Weichenhan D; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Eichhorst B; Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Köln, Germany.
  • Fischer K; Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Köln, Germany.
  • Hallek M; Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Köln, Germany.
  • Kuchenbauer F; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
  • Plass C; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Döhner H; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
  • Stilgenbauer S; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
  • Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Mertens D; Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Int J Cancer ; 142(2): 322-333, 2018 01 15.
Article en En | MEDLINE | ID: mdl-28921505
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Leucemia Linfocítica Crónica de Células B / Regulación Leucémica de la Expresión Génica / Metilación de ADN / Factores de Transcripción NFATC / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Int J Cancer Año: 2018 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Leucemia Linfocítica Crónica de Células B / Regulación Leucémica de la Expresión Génica / Metilación de ADN / Factores de Transcripción NFATC / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Int J Cancer Año: 2018 Tipo del documento: Article País de afiliación: Alemania