Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic ß cells.
Mol Metab
; 6(9): 1024-1039, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-28951826
Palabras clave
ATF, activating transcription factor; CHOP, C/EBP homologous protein; CRISPR, clustered regularly interspaced short palindromic repeats; CReP, constitutive repressor of eIF2α phosphorylation; Diabetes; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Endoplasmic reticulum stress; GCN2, general control non-derepressible-2; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide 1; GWAS, genome-wide association study; HNF1A, hepatocyte nuclear factor 1-α; HRI, heme-regulated inhibitor kinase; IAPP, islet amyloid polypeptide; IER3IP1, immediate early response-3 interacting protein-1; IRE1, inositol-requiring protein-1; ISR, integrated stress response; Insulin; Islet; MEHMO, mental retardation, epilepsy, hypogonadism and -genitalism, microcephaly and obesity; MODY, maturity-onset diabetes of the young; NRF2, nuclear factor, erythroid 2 like 2; PBA, 4-phenyl butyric acid; PERK, PKR-like ER kinase; PKR, protein kinase RNA; PP1, protein phosphatase 1; PPA, phenylpropenoic acid glucoside; Pancreatic ß cell; Pdx1, pancreatic duodenal homeobox 1; RIDD, regulated IRE1-dependent decay; RyR2, type 2 ryanodine receptor/Ca2+ release channel; SERCA, sarcoendoplasmic reticulum Ca2+ ATPase; TUDCA, taurine-conjugated ursodeoxycholic acid derivative; UPR, unfolded protein response; WFS, Wolfram syndrome; XBP1, X-box binding protein 1; eIF2, eukaryotic translation initiation factor 2; eIF2α; hESC, human embryonic stem cell; hPSC, human pluripotent stem cell; hiPSC, human induced pluripotent stem cell; uORF, upstream open reading frame
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor 2 Eucariótico de Iniciación
/
Células Secretoras de Insulina
/
Estrés del Retículo Endoplásmico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Metab
Año:
2017
Tipo del documento:
Article
País de afiliación:
Bélgica