Estrés del Retículo Endoplásmico/fisiología; Factor 2 Eucariótico de Iniciación/metabolismo; Células Secretoras de Insulina/metabolismo; Animales; Apoptosis; Muerte Celular; Diabetes Mellitus/metabolismo; Retículo Endoplásmico/metabolismo; Humanos; Fosforilación; Transducción de Señal; Respuesta de Proteína Desplegada; eIF-2 Quinasa/metabolismo

ATF, activating transcription factor; CHOP, C/EBP homologous protein; CRISPR, clustered regularly interspaced short palindromic repeats; CReP, constitutive repressor of eIF2α phosphorylation; Diabetes; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Endoplasmic reticulum stress; GCN2, general control non-derepressible-2; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide 1; GWAS, genome-wide association study; HNF1A, hepatocyte nuclear factor 1-α; HRI, heme-regulated inhibitor kinase; IAPP, islet amyloid polypeptide; IER3IP1, immediate early response-3 interacting protein-1; IRE1, inositol-requiring protein-1; ISR, integrated stress response; Insulin; Islet; MEHMO, mental retardation, epilepsy, hypogonadism and -genitalism, microcephaly and obesity; MODY, maturity-onset diabetes of the young; NRF2, nuclear factor, erythroid 2 like 2; PBA, 4-phenyl butyric acid; PERK, PKR-like ER kinase; PKR, protein kinase RNA; PP1, protein phosphatase 1; PPA, phenylpropenoic acid glucoside; Pancreatic ß cell; Pdx1, pancreatic duodenal homeobox 1; RIDD, regulated IRE1-dependent decay; RyR2, type 2 ryanodine receptor/Ca2+ release channel; SERCA, sarcoendoplasmic reticulum Ca2+ ATPase; TUDCA, taurine-conjugated ursodeoxycholic acid derivative; UPR, unfolded protein response; WFS, Wolfram syndrome; XBP1, X-box binding protein 1; eIF2, eukaryotic translation initiation factor 2; eIF2α; hESC, human embryonic stem cell; hPSC, human pluripotent stem cell; hiPSC, human induced pluripotent stem cell; uORF, upstream open reading frame