Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway.
Toxicol Rep
; 1: 1143-1151, 2014.
Article
en En
| MEDLINE
| ID: mdl-28962324
ATF-4, Activating transcription factor 4; ATF-6, activating transcription factor 6; BiP, binding immunoglobulin protein; CHOP, CCAAT/enhancer binding protein-homologous protein; CREB, cAMP response element-binding protein; Huh7, human hepatoma cells; Human hepatoma cells; IFN α, interferon α; IFN ß, interferon ß; IP-10, interferon gamma-induced protein 10; IRE-1, inositol-requiring protein 1; IRF-9, interferon regulatory factor 9; ISG-15, interferon-induced 17 kDa protein; ISGs, interferon stiulated genes; MAPK, mitogen-activated protein kinase signaling pathway; NFκB, nuclear factor 'kappa-light-chain-enhancer' of activated B-cells; Noxa, phorbol-12-myristate-13-acetate-induced protein 1; PERK, protein kinase like ER kinase; PP2A, protein phosphatase 2a; Proinflammatory response ;Iinterferon-stimulated genes; STAT1, signal transducer and activator of transcription 1; SiO2-NPs, silica nanoparticles; TNFα, tumor necrosis factor α; Tumor necrosis factor alpha; UPR, unfolded protein response; XBP-1, X-box binding protein 1; eIF2α, eukaryotic initiation factor 2α; p53, TP53-tumorsuppressor-gene
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Toxicol Rep
Año:
2014
Tipo del documento:
Article
País de afiliación:
Suiza