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Inhibiting PI3Kß with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors.
Lynch, James T; Polanska, Urszula M; Delpuech, Oona; Hancox, Urs; Trinidad, Antonio G; Michopoulos, Filippos; Lenaghan, Carol; McEwen, Robert; Bradford, James; Polanski, Radek; Ellston, Rebecca; Avivar-Valderas, Alvaro; Pilling, James; Staniszewska, Anna; Cumberbatch, Marie; Critchlow, Susan E; Cruzalegui, Francisco; Barry, Simon T.
Afiliación
  • Lynch JT; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Polanska UM; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Delpuech O; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Hancox U; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • Trinidad AG; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Michopoulos F; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • Lenaghan C; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • McEwen R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Bradford J; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • Polanski R; Department of Oncology and Metabolism, University of Sheffield, Sheffield, South Yorkshire, United Kingdom.
  • Ellston R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • Avivar-Valderas A; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
  • Pilling J; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom.
  • Staniszewska A; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Cumberbatch M; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Critchlow SE; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
  • Cruzalegui F; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
  • Barry ST; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom. Simon.T.Barry@astrazeneca.com.
Clin Cancer Res ; 23(24): 7584-7595, 2017 Dec 15.
Article en En | MEDLINE | ID: mdl-28972046
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromonas / Fosfohidrolasa PTEN / Fosfatidilinositol 3-Quinasas Clase II / Neoplasias de la Mama Triple Negativas / Compuestos de Anilina Límite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromonas / Fosfohidrolasa PTEN / Fosfatidilinositol 3-Quinasas Clase II / Neoplasias de la Mama Triple Negativas / Compuestos de Anilina Límite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido