Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
J Mol Biol
; 430(2): 207-216, 2018 01 19.
Article
en En
| MEDLINE
| ID: mdl-29017836
ABSTRACT
Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1ß and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its biological functions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
/
Infecciones por Bacterias Gramnegativas
/
Caspasas
/
Inflamasomas
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Bacterias Gramnegativas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos