The Role of B Cells in Carriage and Clearance of Mycoplasma pneumoniae From the Respiratory Tract of Mice.
J Infect Dis
; 217(2): 298-309, 2018 01 04.
Article
en En
| MEDLINE
| ID: mdl-29099932
ABSTRACT
Background:
Carriage of Mycoplasma pneumoniae (Mp) in the nasopharynx is considered a prerequisite for pulmonary infection. It is interesting to note that Mp carriage is also detected after infection. Although B cells are known to be involved in pulmonary Mp clearance, their role in Mp carriage is unknown.Methods:
In this study, we show in a mouse model that Mp persists in the nose after pulmonary infection, similar to humans.Results:
Infection of mice enhanced Mp-specific immunoglobulin (Ig) M and IgG levels in serum and bronchoalveolar lavage fluid. However, nasal washes only contained elevated Mp-specific IgA. These differences in Ig compartmentalization correlated with differences in Mp-specific B cell responses between nose- and lung-draining lymphoid tissues. Moreover, transferred Mp-specific serum Igs had no effect on nasal carriage in B cell-deficient µMT mice, whereas this enabled µMT mice to clear pulmonary Mp infection.Conclusions:
We report the first evidence that humoral immunity is limited in clearing Mp from the upper respiratory tract.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumonía por Mycoplasma
/
Linfocitos B
/
Portador Sano
/
Nasofaringe
/
Mycoplasma pneumoniae
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
2018
Tipo del documento:
Article
País de afiliación:
Países Bajos