AnatomiCuts: Hierarchical clustering of tractography streamlines based on anatomical similarity.
Neuroimage
; 166: 32-45, 2018 02 01.
Article
en En
| MEDLINE
| ID: mdl-29100937
ABSTRACT
Diffusion MRI tractography produces massive sets of streamlines that contain a wealth of information on brain connections. The size of these datasets creates a need for automated clustering methods to group the streamlines into meaningful bundles. Conventional clustering techniques group streamlines based on their spatial coordinates. Neuroanatomists, however, define white-matter bundles based on the anatomical structures that they go through or next to, rather than their spatial coordinates. Thus we propose a similarity measure for clustering streamlines based on their position relative to cortical and subcortical brain regions. We incorporate this measure into a hierarchical clustering algorithm and compare it to a measure that relies on Euclidean distance, using data from the Human Connectome Project. We show that the anatomical similarity measure leads to a 20% improvement in the overlap of clusters with manually labeled tracts. Importantly, this is achieved without introducing any prior information from a tract atlas into the clustering algorithm, therefore without imposing the existence of any named tracts.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Imagen de Difusión Tensora
/
Conectoma
/
Sustancia Blanca
/
Modelos Teóricos
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2018
Tipo del documento:
Article