Honokiol protects pancreatic ß cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2/ARE pathway in vitro and in vivo.

Li, Chen-Guang; Ni, Chang-Lin; Yang, Min; Tang, Yun-Zhao; Li, Zhu; Zhu, Yan-Juan; Jiang, Zhen-Huan; Sun, Bei; Li, Chun-Jun

Li, Chen-Guang; Ni, Chang-Lin; Yang, Min; Tang, Yun-Zhao; Li, Zhu; Zhu, Yan-Juan; Jiang, Zhen-Huan; Sun, Bei; Li, Chun-Jun.

Afiliación

Li CG; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China. Electronic address: lichenguang1005@126.com.
Ni CL; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Yang M; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Tang YZ; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Li Z; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Zhu YJ; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Jiang ZH; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Sun B; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
Li CJ; Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.

Biomed Pharmacother ; 97: 1229-1237, 2018 Jan.

Article en En | MEDLINE | ID: mdl-29145148

Asunto(s)

Compuestos de Bifenilo/farmacología; Diabetes Mellitus Tipo 2/fisiopatología; Células Secretoras de Insulina/efectos de los fármacos; Lignanos/farmacología; Estrés Oxidativo/efectos de los fármacos; Animales; Apoptosis/efectos de los fármacos; Glucemia/metabolismo; Proliferación Celular/efectos de los fármacos; Diabetes Mellitus Experimental/fisiopatología; Depuradores de Radicales Libres/farmacología; Glucagón/metabolismo; Hipoxia/metabolismo; Insulina/sangre; Resistencia a la Insulina; Células Secretoras de Insulina/patología; Factor 2 Relacionado con NF-E2/metabolismo; Ratas; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo; Apnea Obstructiva del Sueño/complicaciones

Palabras clave

Honokiol; Intermittent hypoxia; Nrf2/ARE signaling pathway; Pancreatic ß cell; Type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos de Bifenilo / Lignanos / Estrés Oxidativo / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2018 Tipo del documento: Article

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