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Disturbance in Plasma Metabolic Profile in Different Types of Human Cytomegalovirus-Induced Liver Injury in Infants.
Li, Wei-Wei; Shan, Jin-Jun; Lin, Li-Li; Xie, Tong; He, Li-Li; Yang, Yan; Wang, Shou-Chuan.
Afiliación
  • Li WW; Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Pediatrics, Nanjing, 210023, China.
  • Shan JJ; Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Lin LL; Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Pediatrics, Nanjing, 210023, China.
  • Xie T; Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • He LL; Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Pediatrics, Nanjing, 210023, China.
  • Yang Y; Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatics, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Wang SC; Affiliated Hospital of Nanjing University of Chinese Medicine, Department of Pediatrics, Nanjing, 210023, China.
Sci Rep ; 7(1): 15696, 2017 Nov 16.
Article en En | MEDLINE | ID: mdl-29146975
ABSTRACT
Human cytomegalovirus (HCMV) infection in infants is a global problem and the liver is a target organ of HCMV invasion. However, the mechanism by which HCMV causes different types of liver injury is unclear, and there are many difficulties in the differential diagnosis of HCMV infantile cholestatic hepatopathy (ICH) and extrahepatic biliary atresia (EHBA). We established a non-targeted gas chromatography-mass spectrometry metabolomics method in conjunction with orthogonal partial least squares-discriminate analysis based on 127 plasma samples from healthy controls, and patients with HCMV infantile hepatitis, HCMV ICH, and HCMV EHBA to explore the metabolite profile of different types of HCMV-induced liver injury. Twenty-nine metabolites related to multiple amino acid metabolism disorder, nitrogen metabolism and energy metabolism were identified. Carbamic acid, glutamate, L-aspartic acid, L-homoserine, and noradrenaline for HCMV ICH vs. HCMV EHBA were screened as potential biomarkers and showed excellent discriminant performance. These results not only revealed the potential pathogenesis of HCMV-induced liver injury, but also provided a feasible diagnostic tool for distinguishing EHBA from ICH.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Citomegalovirus / Citomegalovirus / Metabolómica / Hígado Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Citomegalovirus / Citomegalovirus / Metabolómica / Hígado Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China