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Pretargeted PET Imaging Using a Bioorthogonal 18F-Labeled trans-Cyclooctene in an Ovarian Carcinoma Model.
Billaud, Emilie M F; Belderbos, Sarah; Cleeren, Frederik; Maes, Wim; Van de Wouwer, Marlies; Koole, Michel; Verbruggen, Alfons; Himmelreich, Uwe; Geukens, Nick; Bormans, Guy.
Afiliación
  • Billaud EMF; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 821, 3000 Leuven, Belgium.
  • Belderbos S; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, KU Leuven , Campus Gasthuisberg, O&N1, Herestraat 49, Box 505, 3000 Leuven, Belgium.
  • Cleeren F; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 821, 3000 Leuven, Belgium.
  • Maes W; PharmAbs, the KU Leuven Antibody Center, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 820, 3000 Leuven, Belgium.
  • Van de Wouwer M; PharmAbs, the KU Leuven Antibody Center, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 820, 3000 Leuven, Belgium.
  • Koole M; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital and KU Leuven , Herestraat 49, Box 7003, 3000 Leuven, Belgium.
  • Verbruggen A; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 821, 3000 Leuven, Belgium.
  • Himmelreich U; Biomedical MRI/MoSAIC, Department of Imaging and Pathology, KU Leuven , Campus Gasthuisberg, O&N1, Herestraat 49, Box 505, 3000 Leuven, Belgium.
  • Geukens N; PharmAbs, the KU Leuven Antibody Center, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 820, 3000 Leuven, Belgium.
  • Bormans G; Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , Campus Gasthuisberg, O&N2, Herestraat 49, Box 821, 3000 Leuven, Belgium.
Bioconjug Chem ; 28(12): 2915-2920, 2017 Dec 20.
Article en En | MEDLINE | ID: mdl-29191024
ABSTRACT
In cancer research, pretargeted positron emission tomography (PET) imaging has emerged as an effective two-step approach that combines the excellent target affinity and selectivity of antibodies with the advantages of using short-lived radionuclides such as fluorine-18. One possible approach is based on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between tetrazines and trans-cyclooctene (TCO) derivatives. Here, we report the first successful use of an 18F-labeled small TCO compound, [18F]1 recently developed in our laboratory, to perform pretargeted immuno-PET imaging. The study was performed in an ovarian carcinoma mouse model, using a trastuzumab-tetrazine conjugate.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Radioisótopos de Flúor / Ciclooctanos / Tomografía de Emisión de Positrones Límite: Animals / Female / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Radioisótopos de Flúor / Ciclooctanos / Tomografía de Emisión de Positrones Límite: Animals / Female / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica