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Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.
Handley, Renee R; Reid, Suzanne J; Brauning, Rudiger; Maclean, Paul; Mears, Emily R; Fourie, Imche; Patassini, Stefano; Cooper, Garth J S; Rudiger, Skye R; McLaughlan, Clive J; Verma, Paul J; Gusella, James F; MacDonald, Marcy E; Waldvogel, Henry J; Bawden, C Simon; Faull, Richard L M; Snell, Russell G.
Afiliación
  • Handley RR; Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.
  • Reid SJ; Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.
  • Brauning R; Invermay Agricultural Centre, AgResearch Ltd., Mosgiel 9053, New Zealand.
  • Maclean P; Invermay Agricultural Centre, AgResearch Ltd., Mosgiel 9053, New Zealand.
  • Mears ER; Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.
  • Fourie I; Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.
  • Patassini S; Centre for Brain Research, Faculty of Medical and Health Science, The University of Auckland, Auckland 1023, New Zealand.
  • Cooper GJS; Centre for Advanced Discovery and Experimental Therapeutics, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom.
  • Rudiger SR; Centre for Brain Research, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand.
  • McLaughlan CJ; Centre for Advanced Discovery and Experimental Therapeutics, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom.
  • Verma PJ; Molecular Biology and Reproductive Technology Laboratories, South Australian Research and Development Institute, Adelaide, SA 5350, Australia.
  • Gusella JF; Molecular Biology and Reproductive Technology Laboratories, South Australian Research and Development Institute, Adelaide, SA 5350, Australia.
  • MacDonald ME; Molecular Biology and Reproductive Technology Laboratories, South Australian Research and Development Institute, Adelaide, SA 5350, Australia.
  • Waldvogel HJ; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA 02114.
  • Bawden CS; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston MA 02114.
  • Faull RLM; Centre for Brain Research, Faculty of Medical and Health Science, The University of Auckland, Auckland 1023, New Zealand.
  • Snell RG; Molecular Biology and Reproductive Technology Laboratories, South Australian Research and Development Institute, Adelaide, SA 5350, Australia.
Proc Natl Acad Sci U S A ; 114(52): E11293-E11302, 2017 12 26.
Article en En | MEDLINE | ID: mdl-29229845
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Urea / Enfermedad de Huntington / Cuerpo Estriado Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Urea / Enfermedad de Huntington / Cuerpo Estriado Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda