Molecular Insights into Function and Competitive Inhibition of <i>Pseudomonas aeruginosa</i> Multiple Virulence Factor Regulator.

Kitao, Tomoe; Lepine, Francois; Babloudi, Seda; Walte, Frederick; Steinbacher, Stefan; Maskos, Klaus; Blaesse, Michael; Negri, Michele; Pucci, Michael; Zahler, Bob; Felici, Antonio; Rahme, Laurence G

Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator.

Kitao, Tomoe; Lepine, Francois; Babloudi, Seda; Walte, Frederick; Steinbacher, Stefan; Maskos, Klaus; Blaesse, Michael; Negri, Michele; Pucci, Michael; Zahler, Bob; Felici, Antonio; Rahme, Laurence G.

Afiliación

Kitao T; Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lepine F; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Babloudi S; Shriners Hospitals for Children Boston, Boston, Massachusetts, USA.
Walte F; INRS, Institut Armand Frappier, Laval, Québec, Canada.
Steinbacher S; Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Maskos K; Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Blaesse M; Proteros Biostructures, Planegg-Martinsried, Germany.
Negri M; Proteros Biostructures, Planegg-Martinsried, Germany.
Pucci M; Proteros Biostructures, Planegg-Martinsried, Germany.
Zahler B; Microbiology Unit, Aptuit Centre of Drug Discovery and Development, Verona, Italy.
Felici A; Spero Therapeutics, Cambridge, Massachusetts, USA.
Rahme LG; Spero Therapeutics, Cambridge, Massachusetts, USA.

mBio ; 9(1)2018 01 16.

Article en En | MEDLINE | ID: mdl-29339431

Asunto(s)

Proteínas Bacterianas/química; Inhibidores Enzimáticos/química; Pseudomonas aeruginosa/enzimología; Factores de Virulencia/química; Proteínas Bacterianas/metabolismo; Bencimidazoles/química; Bencimidazoles/metabolismo; Sitios de Unión; Cristalografía por Rayos X; Inhibidores Enzimáticos/metabolismo; Modelos Moleculares; Unión Proteica; Conformación Proteica; Resonancia por Plasmón de Superficie; Factores de Virulencia/metabolismo

Palabras clave

MvfR; PqsR; Pseudomonas aeruginosa; X-ray crystallography; antivirulence; benzamine-benzimidazole inhibitors; competitive inhibition; infection; inhibition; pathogenesis; quorum sensing; structural analysis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Proteínas Bacterianas / Factores de Virulencia / Inhibidores Enzimáticos Tipo de estudio: Prognostic_studies Idioma: En Revista: MBio Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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