Protectiveness of Cu water quality criteria against impairment of behavior and chemo/mechanosensory responses: An update.

A meta-analysis was conducted of studies that reported behavior and chemo/mechanosensory responses by fish, amphibians, and aquatic invertebrates in Cu-containing waters and also reported sufficient water chemistry for calculation of hardness-based and biotic ligand model (BLM)-based water quality criteria (WQC) for Cu. The calculated WQC concentrations were then compared with the corresponding 20% impairment concentrations (IC20) of Cu for those behavior and chemo/mechanosensory responses. The hardness-based acute and chronic WQC for Cu would not have been protective (i.e., the IC20 would have been lower than the WQC) in 33.6 and 26.2%, respectively, of the 107 combined behavior- and chemo/mechanosensory-response cases that also had adequate water chemistry data for BLM-based WQC calculations (32.7% inconclusive). In comparison, the BLM-based acute and chronic WQC for Cu would not have been protective in only 10.3 and 4.7%, respectively, of the same 107 cases (29.9% inconclusive). To improve evaluations of regulatory effectiveness, researchers conducting aquatic Cu toxicity tests should measure and report complete BLM-input water chemistry and bracket the hardness-based and BLM-based WQC concentrations for Cu that would be applicable in their exposure waters. This meta-analysis demonstrates that, overall, the BLM-based WQC for Cu were considerably more protective than the hardness-based WQC for Cu against impairment of behavior and chemo/mechanosensory responses. Environ Toxicol Chem 2018;37:1260-1279. © 2018 SETAC.