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Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
Nasser, Arafat; Møller, Anette Torvin; Hellmund, Vibe; Thorborg, Sidsel Salling; Jespersgaard, Cathrine; Bjerrum, Ole J; Dupont, Erik; Nachman, Gösta; Lykkesfeldt, Jens; Jensen, Troels Staehelin; Møller, Lisbeth Birk.
Afiliación
  • Nasser A; Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
  • Møller AT; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Ø, Denmark.
  • Hellmund V; Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, Århus, Denmark.
  • Thorborg SS; Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, Århus, Denmark.
  • Jespersgaard C; Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
  • Bjerrum OJ; Applied Human Molecular Genetics, Clinical Genetic Clinic, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
  • Dupont E; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Ø, Denmark.
  • Nachman G; Department of Neurology, Aarhus University Hospital, Århus, Denmark.
  • Lykkesfeldt J; Department of Biology, Section of Ecology and Evolution, University of Copenhagen, Copenhagen Ø, Denmark.
  • Jensen TS; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
  • Møller LB; Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, Århus, Denmark.
Pain ; 159(6): 1012-1024, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29470312
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Biopterinas / Trastornos Distónicos / GTP Ciclohidrolasa / Mutación Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2018 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Biopterinas / Trastornos Distónicos / GTP Ciclohidrolasa / Mutación Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2018 Tipo del documento: Article País de afiliación: Dinamarca