Your browser doesn't support javascript.
loading
Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats.
Kading, Rebekah C; Kityo, Robert M; Mossel, Eric C; Borland, Erin M; Nakayiki, Teddie; Nalikka, Betty; Nyakarahuka, Luke; Ledermann, Jeremy P; Panella, Nicholas A; Gilbert, Amy T; Crabtree, Mary B; Peterhans, Julian Kerbis; Towner, Jonathan S; Amman, Brian R; Sealy, Tara K; Nichol, Stuart T; Powers, Ann M; Lutwama, Julius J; Miller, Barry R.
Afiliación
  • Kading RC; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Kityo RM; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Mossel EC; Department of Biological Sciences, Makerere University, Kampala, Uganda.
  • Borland EM; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Nakayiki T; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Nalikka B; Department of Arbovirology, Emerging, and Re-emerging Viral Infections, Uganda Virus Research Institute, Entebbe, Uganda.
  • Nyakarahuka L; Department of Biological Sciences, Makerere University, Kampala, Uganda.
  • Ledermann JP; Department of Arbovirology, Emerging, and Re-emerging Viral Infections, Uganda Virus Research Institute, Entebbe, Uganda.
  • Panella NA; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Gilbert AT; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Crabtree MB; Division of High Consequence Pathogens, Rabies and Poxvirus Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Peterhans JK; USA Department of Agriculture, Animal and Plant Health Inspection Service, Fort Collins, CO, USA.
  • Towner JS; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
  • Amman BR; College of Professional Studies, Roosevelt University & Collections & Research, The Field Museum of Natural History, Chicago, IL, USA.
  • Sealy TK; Division of High Consequence Pathogens, Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Nichol ST; Division of High Consequence Pathogens, Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Powers AM; Division of High Consequence Pathogens, Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Lutwama JJ; Division of High Consequence Pathogens, Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Miller BR; Division of Vector-borne Diseases, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Infect Ecol Epidemiol ; 8(1): 1439215, 2018.
Article en En | MEDLINE | ID: mdl-29511459
ABSTRACT

Introduction:

A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials and

methods:

Insectivorous and fruit bats were captured from multiple locations throughout Uganda during 2009 and 2011-2013. All serum samples were tested for neutralizing antibodies against West Nile virus (WNV), yellow fever virus (YFV), dengue 2 virus (DENV-2), Zika virus (ZIKV), Babanki virus (BBKV), and Rift Valley fever virus (RVFV) by plaque reduction neutralization test (PRNT). Sera from up to 626 bats were screened for antibodies against each virus. Results and

Discussion:

 Key findings include the presence of neutralizing antibodies against RVFV in 5/52 (9.6%) of little epauletted fruit bats (Epomophorus labiatus) captured from Kawuku and 3/54 (5.6%) Egyptian rousette bats from Kasokero cave. Antibodies reactive to flaviviruses were widespread across bat taxa and sampling locations.

Conclusion:

The data presented demonstrate the widespread exposure of bats in Uganda to arboviruses, and highlight particular virus-bat associations that warrant further investigation.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Infect Ecol Epidemiol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Infect Ecol Epidemiol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos