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Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.
Tynkkynen, Juho; Chouraki, Vincent; van der Lee, Sven J; Hernesniemi, Jussi; Yang, Qiong; Li, Shuo; Beiser, Alexa; Larson, Martin G; Sääksjärvi, Katri; Shipley, Martin J; Singh-Manoux, Archana; Gerszten, Robert E; Wang, Thomas J; Havulinna, Aki S; Würtz, Peter; Fischer, Krista; Demirkan, Ayse; Ikram, M Arfan; Amin, Najaf; Lehtimäki, Terho; Kähönen, Mika; Perola, Markus; Metspalu, Andres; Kangas, Antti J; Soininen, Pasi; Ala-Korpela, Mika; Vasan, Ramachandran S; Kivimäki, Mika; van Duijn, Cornelia M; Seshadri, Sudha; Salomaa, Veikko.
Afiliación
  • Tynkkynen J; Department of Cardiology, Tays Heart Hospital, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Chouraki V; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Framingham, MA, USA; Lille University, Inserm, Lille University Hospital, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Labex
  • van der Lee SJ; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Hernesniemi J; Department of Cardiology, Tays Heart Hospital, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Yang Q; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Li S; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Beiser A; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Larson MG; The Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Sääksjärvi K; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
  • Shipley MJ; Department of Epidemiology and Public Health, University College London, London, UK.
  • Singh-Manoux A; Department of Epidemiology and Public Health, University College London, London, UK; INSERM, U1018, Centre for Research in Epidemiology and Population Health, France.
  • Gerszten RE; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Wang TJ; Vanderbilt Heart and Vascular Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Havulinna AS; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
  • Würtz P; Nightingale Health Ltd, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
  • Fischer K; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Demirkan A; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Ikram MA; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
  • Amin N; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
  • Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Perola M; Department of Health, National Institute for Health and Welfare, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Kangas AJ; Nightingale Health Ltd, Helsinki, Finland.
  • Soininen P; Nightingale Health Ltd, Helsinki, Finland; Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Ala-Korpela M; Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK; Medical Research
  • Vasan RS; The Framingham Heart Study, Framingham, MA, USA; Department of Medicine, Sections of Preventive Medicine and Cardiology, Boston University School of Medicine, Boston, MA, USA.
  • Kivimäki M; Department of Epidemiology and Public Health, University College London, London, UK; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • van Duijn CM; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands; Leiden Academic Center for Drug Reseach (LACDR), Leiden University, Leiden, The Netherlands.
  • Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Framingham, MA, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA. Electronic address: suseshad@bu.edu
  • Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland. Electronic address: veikko.salomaa@thl.fi.
Alzheimers Dement ; 14(6): 723-733, 2018 06.
Article en En | MEDLINE | ID: mdl-29519576
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Demencia / Metabolómica / Enfermedad de Alzheimer / Aminoácidos de Cadena Ramificada Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2018 Tipo del documento: Article País de afiliación: Finlandia
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Demencia / Metabolómica / Enfermedad de Alzheimer / Aminoácidos de Cadena Ramificada Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2018 Tipo del documento: Article País de afiliación: Finlandia