Lipocortin inhibition of extracellular and intracellular phospholipases A2 is substrate concentration dependent.
FEBS Lett
; 219(1): 176-80, 1987 Jul 13.
Article
en En
| MEDLINE
| ID: mdl-2954856
ABSTRACT
Hydrolysis of Escherichia coli membrane phospholipids by pancreatic phospholipase A2 was inhibited by lipocortin from human monocytes in a substrate dependent manner. Inhibition was completely overcome at substrate concentrations above 250 microM. Lipocortin also inhibited partially purified preparations of two intracellular phospholipases A2 isolated from rat liver mitochondria and rat platelets when these enzymes were assayed at low micromolar concentrations of phosphatidylethanolamine. Inhibition gradually decreased with increasing substrate concentrations both for pancreatic and platelet phospholipase A2 and became completely abolished above 15 and 50 microM phosphatidylethanolamine, respectively.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfolipasas
/
Fosfolipasas A
/
Glicoproteínas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1987
Tipo del documento:
Article