Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer.

Wang, Bei; Zhou, Tan-Yang; Nie, Chun-Hui; Wan, Da-Long; Zheng, Shu-Sen

Wang, Bei; Zhou, Tan-Yang; Nie, Chun-Hui; Wan, Da-Long; Zheng, Shu-Sen.

Afiliación

Wang B; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.
Zhou TY; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.
Nie CH; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.
Wan DL; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.
Zheng SS; Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China. Electronic address: shusenzheng@zju.edu.cn.

Biochem Biophys Res Commun ; 499(2): 156-163, 2018 05 05.

Article en En | MEDLINE | ID: mdl-29548826

Asunto(s)

Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Lactonas/farmacología; Neoplasias Hepáticas/patología; Especies Reactivas de Oxígeno/metabolismo; Sesquiterpenos/farmacología; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo; Animales; Autofagosomas/efectos de los fármacos; Autofagosomas/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Humanos; Neoplasias Hepáticas/ultraestructura; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; Transducción de Señal/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Apoptosis and autophagy; Bigelovin; Liver cancer; ROS; mTOR

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sesquiterpenos / Autofagia / Transducción de Señal / Especies Reactivas de Oxígeno / Apoptosis / Serina-Treonina Quinasas TOR / Lactonas / Neoplasias Hepáticas Límite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: China

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