Agonists of the Î³-aminobutyric acid type B (GABA<sub>B</sub>) receptor derived from ß-hydroxy and ß-amino difluoromethyl ketones.

Sowaileh, Munia F; Salyer, Amy E; Roy, Kuldeep K; John, Jinu P; Woods, James R; Doerksen, Robert J; Hockerman, Gregory H; Colby, David A

Agonists of the Î³-aminobutyric acid type B (GABA_B) receptor derived from ß-hydroxy and ß-amino difluoromethyl ketones.

Sowaileh, Munia F; Salyer, Amy E; Roy, Kuldeep K; John, Jinu P; Woods, James R; Doerksen, Robert J; Hockerman, Gregory H; Colby, David A.

Afiliación

Sowaileh MF; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.
Salyer AE; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.
Roy KK; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.
John JP; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.
Woods JR; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.
Doerksen RJ; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States.
Hockerman GH; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.
Colby DA; Department of BioMolecular Sciences, University of Mississippi, University, MS 38677, United States. Electronic address: dacolby@olemiss.edu.

Bioorg Med Chem Lett ; 28(16): 2697-2700, 2018 09 01.

Article en En | MEDLINE | ID: mdl-29657102

Asunto(s)

Agonistas de Receptores GABA-B/farmacología; Cetonas/farmacología; Propilaminas/farmacología; Sitios de Unión; Agonistas de Receptores GABA-B/síntesis química; Agonistas de Receptores GABA-B/química; Células HEK293; Humanos; Cetonas/síntesis química; Cetonas/química; Simulación del Acoplamiento Molecular; Propilaminas/síntesis química; Propilaminas/química; Receptores de GABA-B/química; Estereoisomerismo; Relación Estructura-Actividad

Palabras clave

Agonist; Fluorine; GABA receptor; GABA-B; Gamma-aminobutyric acid

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Propilaminas / Agonistas de Receptores GABA-B / Cetonas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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