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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
Filbin, Mariella G; Tirosh, Itay; Hovestadt, Volker; Shaw, McKenzie L; Escalante, Leah E; Mathewson, Nathan D; Neftel, Cyril; Frank, Nelli; Pelton, Kristine; Hebert, Christine M; Haberler, Christine; Yizhak, Keren; Gojo, Johannes; Egervari, Kristof; Mount, Christopher; van Galen, Peter; Bonal, Dennis M; Nguyen, Quang-De; Beck, Alexander; Sinai, Claire; Czech, Thomas; Dorfer, Christian; Goumnerova, Liliana; Lavarino, Cinzia; Carcaboso, Angel M; Mora, Jaume; Mylvaganam, Ravindra; Luo, Christina C; Peyrl, Andreas; Popovic, Mara; Azizi, Amedeo; Batchelor, Tracy T; Frosch, Matthew P; Martinez-Lage, Maria; Kieran, Mark W; Bandopadhayay, Pratiti; Beroukhim, Rameen; Fritsch, Gerhard; Getz, Gad; Rozenblatt-Rosen, Orit; Wucherpfennig, Kai W; Louis, David N; Monje, Michelle; Slavc, Irene; Ligon, Keith L; Golub, Todd R; Regev, Aviv; Bernstein, Bradley E; Suvà, Mario L.
Afiliación
  • Filbin MG; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Tirosh I; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA.
  • Hovestadt V; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Shaw ML; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Escalante LE; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Mathewson ND; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Neftel C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Frank N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Pelton K; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Hebert CM; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Haberler C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Yizhak K; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Gojo J; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Egervari K; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Mount C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • van Galen P; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Bonal DM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Nguyen QD; Department of Cancer Immunology and Virology, Department of Microbiology and Immunobiology, Department of Neurology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
  • Beck A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Sinai C; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Czech T; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Dorfer C; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
  • Goumnerova L; Children's Cancer Research Institute (CCRI), St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria.
  • Lavarino C; Department of Oncologic Pathology, Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Carcaboso AM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Mora J; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Mylvaganam R; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Luo CC; Institute of Neurology, Medical University of Vienna, Vienna, Austria.
  • Peyrl A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Popovic M; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Azizi A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Batchelor TT; Departments of Neurology, Neurosurgery, Pediatrics, and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Frosch MP; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Martinez-Lage M; Klarman Cell Observatory, Broad Institute of Harvard and Massachussetts Institute of Technology (MIT), Cambridge, MA 02142, USA.
  • Kieran MW; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Bandopadhayay P; Center for Biomedical Imaging in Oncology, Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Beroukhim R; Center for Biomedical Imaging in Oncology, Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Fritsch G; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Getz G; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA.
  • Rozenblatt-Rosen O; Department of Oncologic Pathology, Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Wucherpfennig KW; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  • Louis DN; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  • Monje M; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA.
  • Slavc I; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Ligon KL; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Golub TR; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
  • Regev A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Suvà ML; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Science ; 360(6386): 331-335, 2018 04 20.
Article en En | MEDLINE | ID: mdl-29674595
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oncogenes / Neoplasias Encefálicas / Oligodendroglía / Carcinogénesis / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oncogenes / Neoplasias Encefálicas / Oligodendroglía / Carcinogénesis / Glioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Science Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos