Tolbutamide enhances insulin action on gluconeogenesis and on fructose 2,6-bisphosphate levels in isolated rat hepatocytes.
Diabete Metab
; 14(6): 712-6, 1988 Dec.
Article
en En
| MEDLINE
| ID: mdl-2977593
ABSTRACT
In hepatocytes isolated from fed rats and incubated either under basal conditions or in the presence of glucagon, tolbutamide reduced gluconeogenesis from (U-14C) pyruvate by increasing the cellular concentration of fructose 2,6-bisphosphate. Furthermore, this sulfonylurea enhanced the inhibitory action of insulin on glucagon-stimulated gluconeogenesis; this effect was accompanied by a more marked increase of the cellular concentration of fructose 2,6-bisphosphate than that elicited by either insulin or the sulfonylurea alone. In connection with this, tolbutamide--without significant modification of cellular cyclic AMP levels--raised the proportion of 6-phosphofructo 2-kinase in active form in hepatocytes incubated either under basal conditions or in the presence of glucagon, and reinforced the action of insulin in antagonizing the glucagon-mediated inactivation of this enzyme.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tolbutamida
/
Fructosadifosfatos
/
Gluconeogénesis
/
Hexosadifosfatos
/
Insulina
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Diabete Metab
Año:
1988
Tipo del documento:
Article
País de afiliación:
España