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Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.
Zhang, Yajia; Pitchiaya, Sethuramasundaram; Cieslik, Marcin; Niknafs, Yashar S; Tien, Jean C-Y; Hosono, Yasuyuki; Iyer, Matthew K; Yazdani, Sahr; Subramaniam, Shruthi; Shukla, Sudhanshu K; Jiang, Xia; Wang, Lisha; Liu, Tzu-Ying; Uhl, Michael; Gawronski, Alexander R; Qiao, Yuanyuan; Xiao, Lanbo; Dhanasekaran, Saravana M; Juckette, Kristin M; Kunju, Lakshmi P; Cao, Xuhong; Patel, Utsav; Batish, Mona; Shukla, Girish C; Paulsen, Michelle T; Ljungman, Mats; Jiang, Hui; Mehra, Rohit; Backofen, Rolf; Sahinalp, Cenk S; Freier, Susan M; Watt, Andrew T; Guo, Shuling; Wei, John T; Feng, Felix Y; Malik, Rohit; Chinnaiyan, Arul M.
Afiliación
  • Zhang Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Pitchiaya S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Cieslik M; Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, MI, USA.
  • Niknafs YS; Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA.
  • Tien JC; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Hosono Y; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Iyer MK; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Yazdani S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Subramaniam S; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Shukla SK; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.
  • Jiang X; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Wang L; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Liu TY; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Uhl M; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Gawronski AR; Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA.
  • Qiao Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Xiao L; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Dhanasekaran SM; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Juckette KM; Department of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, India.
  • Kunju LP; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Cao X; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Patel U; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Batish M; Department of Computer Science and Centre for Biological Signaling Studies (BIOSS), University of Freiburg, Freiburg, Germany.
  • Shukla GC; School of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.
  • Paulsen MT; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Ljungman M; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Jiang H; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Mehra R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Backofen R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Sahinalp CS; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Freier SM; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Watt AT; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Guo S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Wei JT; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Feng FY; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Malik R; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.
  • Chinnaiyan AM; New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Nat Genet ; 50(6): 814-824, 2018 06.
Article en En | MEDLINE | ID: mdl-29808028
The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Receptores Androgénicos / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Receptores Androgénicos / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos