Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1,2,3-triazolyl-methyl-indoline-2,3-diones.

Thakur, Ravi Kumar; Joshi, Prince; Baranwal, Pragati; Sharma, Gaurav; Shukla, Sanjeev K; Tripathi, Renu; Tripathi, Rama Pati

Thakur, Ravi Kumar; Joshi, Prince; Baranwal, Pragati; Sharma, Gaurav; Shukla, Sanjeev K; Tripathi, Renu; Tripathi, Rama Pati.

Afiliación

Thakur RK; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Joshi P; Parasitology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Baranwal P; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Sharma G; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Shukla SK; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: skshukla@cdri.res.in.
Tripathi R; Parasitology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India. Electronic address: renu1113@rediffmail.com.
Tripathi RP; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India. Electronic address: rpt.cdri@gmail.com.

Eur J Med Chem ; 155: 764-771, 2018 Jul 15.

Article en En | MEDLINE | ID: mdl-29940466

Asunto(s)

Antimaláricos/farmacología; Hidrazonas/farmacología; Indoles/farmacología; Plasmodium falciparum/efectos de los fármacos; Triazoles/farmacología; Antimaláricos/síntesis química; Antimaláricos/química; Relación Dosis-Respuesta a Droga; Glicosilación; Hidrazonas/química; Indoles/química; Estructura Molecular; Pruebas de Sensibilidad Parasitaria; Relación Estructura-Actividad; Triazoles/síntesis química; Triazoles/química

Palabras clave

Antiplasmodial activity; Glycosylation; Hydrazones; Isatin; Triazole

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Triazoles / Hidrazonas / Indoles / Antimaláricos Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: India

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