Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions.

Geiger-Schuller, Kathryn; Sforza, Kevin; Yuhas, Max; Parmeggiani, Fabio; Baker, David; Barrick, Doug

Geiger-Schuller, Kathryn; Sforza, Kevin; Yuhas, Max; Parmeggiani, Fabio; Baker, David; Barrick, Doug.

Afiliación

Geiger-Schuller K; Department of Biophysics and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Sforza K; Department of Biophysics and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Yuhas M; Department of Biophysics and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Parmeggiani F; Institute for Protein Design, University of Washington, Seattle, WA 98195.
Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195.
Barrick D; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195.

Proc Natl Acad Sci U S A ; 115(29): 7539-7544, 2018 07 17.

Article en En | MEDLINE | ID: mdl-29959204

Asunto(s)

Proteínas de Escherichia coli/química; Escherichia coli/química; Secuencias Hélice-Asa-Hélice; Modelos Moleculares; Análisis de Secuencia de Proteína/métodos

Palabras clave

DHRs; Ising model; Rosetta; protein design; repeat proteins

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Modelos Moleculares / Secuencias Hélice-Asa-Hélice / Análisis de Secuencia de Proteína / Proteínas de Escherichia coli / Escherichia coli Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

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