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Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library.
Merkouris, Spyros; Barde, Yves-Alain; Binley, Kate E; Allen, Nicholas D; Stepanov, Alexey V; Wu, Nicholas C; Grande, Geramie; Lin, Chih-Wei; Li, Meng; Nan, Xinsheng; Chacon-Fernandez, Pedro; DiStefano, Peter S; Lindsay, Ronald M; Lerner, Richard A; Xie, Jia.
Afiliación
  • Merkouris S; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Barde YA; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Binley KE; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Allen ND; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Stepanov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
  • Wu NC; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Grande G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Lin CW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Li M; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Nan X; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • Chacon-Fernandez P; School of Biosciences, Cardiff University, CF10 3AX Cardiff, United Kingdom.
  • DiStefano PS; Zebra Biologics, Concord, MA 01742.
  • Lindsay RM; Zebra Biologics, Concord, MA 01742.
  • Lerner RA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; rlerner@scripps.edu jiaxie@scripps.edu.
  • Xie J; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; rlerner@scripps.edu jiaxie@scripps.edu.
Proc Natl Acad Sci U S A ; 115(30): E7023-E7032, 2018 07 24.
Article en En | MEDLINE | ID: mdl-29987039
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Glicoproteínas de Membrana / Transducción de Señal / Biblioteca de Genes / Comunicación Autocrina / Receptor trkB / Anticuerpos de Cadena Única / Neuronas GABAérgicas Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Glicoproteínas de Membrana / Transducción de Señal / Biblioteca de Genes / Comunicación Autocrina / Receptor trkB / Anticuerpos de Cadena Única / Neuronas GABAérgicas Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido