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Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.
Baliga, Reshma S; Preedy, Michael E J; Dukinfield, Matthew S; Chu, Sandy M; Aubdool, Aisah A; Bubb, Kristen J; Moyes, Amie J; Tones, Michael A; Hobbs, Adrian J.
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  • Baliga RS; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Preedy MEJ; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Dukinfield MS; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Chu SM; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Aubdool AA; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Bubb KJ; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Moyes AJ; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
  • Tones MA; Pfizer, Inc., St. Louis, MO 63198.
  • Hobbs AJ; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, EC1M 6BQ London, United Kingdom; a.j.hobbs@qmul.ac.uk.
Proc Natl Acad Sci U S A ; 115(31): E7428-E7437, 2018 07 31.
Article en En | MEDLINE | ID: mdl-30012589
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Transducción de Señal / GMP Cíclico / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 2 / Guanilato Ciclasa / Insuficiencia Cardíaca / Óxido Nítrico Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Transducción de Señal / GMP Cíclico / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 2 / Guanilato Ciclasa / Insuficiencia Cardíaca / Óxido Nítrico Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido