Glycans as critical regulators of gut immunity in homeostasis and disease.
Cell Immunol
; 333: 9-18, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-30049413
ABSTRACT
The diversity of glycans expression within a cell or an organism is enormous and the amount of relevant biological information that each glycan structure encodes is far from being clarified. The importance of glycans in health and life sciences is highlighted by their multiple functional implications in different cellular and molecular biology processes with impact in homeostasis and diseases, such as cancer and inflammatory conditions. Glycans actively participate in the regulatory circuits that govern both innate and adaptive immune response. Changes in the glycans repertoire occur during the transition from normal to inflamed conditions and the aberrant expression of glycans dictates either pro-inflammatory or anti-inflammatory responses. This review summarizes how glycans integrate the regulatory networks of immune response with a focus on gut immunity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Inmunidad Adaptativa
/
Homeostasis
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Immunol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Portugal