RheoScale: A tool to aggregate and quantify experimentally determined substitution outcomes for multiple variants at individual protein positions.

Hodges, Abby M; Fenton, Aron W; Dougherty, Larissa L; Overholt, Andrew C; Swint-Kruse, Liskin

Hodges, Abby M; Fenton, Aron W; Dougherty, Larissa L; Overholt, Andrew C; Swint-Kruse, Liskin.

Afiliación

Hodges AM; Department of Natural, Health, and Mathematical Sciences, MidAmerica Nazarene University, Olathe, Kansas, USA.
Fenton AW; The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Dougherty LL; The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Overholt AC; Department of Natural, Health, and Mathematical Sciences, MidAmerica Nazarene University, Olathe, Kansas, USA.
Swint-Kruse L; The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA.

Hum Mutat ; 39(12): 1814-1826, 2018 12.

Article en En | MEDLINE | ID: mdl-30117637

Asunto(s)

Sustitución de Aminoácidos; Biología Computacional/métodos; Proteínas/química; Humanos; Modelos Moleculares; Conformación Proteica; Estabilidad Proteica; Proteínas/genética; Programas Informáticos

Palabras clave

LacI/GalR; TIM barrel; deep mutational scanning; personalized medicine; protein; pyruvate kinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Biología Computacional / Sustitución de Aminoácidos Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Hum Mutat Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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