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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.
Makino, Chie; Watanabe, Akiko; Deguchi, Tsuneo; Shiozawa, Hideyuki; Schreck, Ilona; Rozehnal, Veronika; Ishizuka, Tomoko; Watanabe, Nobuaki; Ando, Osamu; Murayama, Norie; Yamazaki, Hiroshi.
Afiliación
  • Makino C; a Drug Metabolism and Pharmacokinetics Research Laboratories , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Watanabe A; a Drug Metabolism and Pharmacokinetics Research Laboratories , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Deguchi T; b Biomarker Department , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Shiozawa H; a Drug Metabolism and Pharmacokinetics Research Laboratories , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Schreck I; c Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH , Munich , Germany.
  • Rozehnal V; c Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH , Munich , Germany.
  • Ishizuka T; d Clinical Pharmacology Department , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Watanabe N; b Biomarker Department , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Ando O; a Drug Metabolism and Pharmacokinetics Research Laboratories , Daiichi Sankyo Co., Ltd . Tokyo , Japan.
  • Murayama N; e Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University, Machida , Tokyo , Japan.
  • Yamazaki H; e Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University, Machida , Tokyo , Japan.
Xenobiotica ; 49(8): 961-969, 2019 Aug.
Article en En | MEDLINE | ID: mdl-30124356
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Benzamidas / Ciclopropanos / Receptores Acoplados a Proteínas G / Redes y Vías Metabólicas Límite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Benzamidas / Ciclopropanos / Receptores Acoplados a Proteínas G / Redes y Vías Metabólicas Límite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Año: 2019 Tipo del documento: Article País de afiliación: Japón