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The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Xiang, Xianyuan; Piers, Thomas M; Wefers, Benedikt; Zhu, Kaichuan; Mallach, Anna; Brunner, Bettina; Kleinberger, Gernot; Song, Wilbur; Colonna, Marco; Herms, Jochen; Wurst, Wolfgang; Pocock, Jennifer M; Haass, Christian.
Afiliación
  • Xiang X; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Piers TM; Graduate School of Systemic Neuroscience, Ludwig- Maximilians- University Munich, Munich, Germany.
  • Wefers B; Department of Neuroinflammation, Cell Signalling Lab, University College London Institute of Neurology, WC1N 1PJ, London, UK.
  • Zhu K; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Mallach A; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Brunner B; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Kleinberger G; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Song W; Department of Neuroinflammation, Cell Signalling Lab, University College London Institute of Neurology, WC1N 1PJ, London, UK.
  • Colonna M; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Herms J; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Wurst W; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Pocock JM; Department of Immunology and Pathology, Washington University in St. Louis, St. Louis, MO, USA.
  • Haass C; Department of Immunology and Pathology, Washington University in St. Louis, St. Louis, MO, USA.
Mol Neurodegener ; 13(1): 49, 2018 09 06.
Article en En | MEDLINE | ID: mdl-30185230
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Predisposición Genética a la Enfermedad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mol Neurodegener Año: 2018 Tipo del documento: Article País de afiliación: Alemania
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Predisposición Genética a la Enfermedad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mol Neurodegener Año: 2018 Tipo del documento: Article País de afiliación: Alemania