Vistriterpenoids A and B, Two New 24-Nor-oleanane Triterpenoids from Dodonaea viscosa.

Wang, Xiao-Hang; Zhu, Ke-Xin; Li, Jing-Ya; Lei, Chun; Hou, Ai-Jun

Wang, Xiao-Hang; Zhu, Ke-Xin; Li, Jing-Ya; Lei, Chun; Hou, Ai-Jun.

Afiliación

Wang XH; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
Zhu KX; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P. R. China.
Li JY; University of Chinese Academy of Sciences, No.19âA Yuquan Road, Beijing, 100049, P. R. China.
Lei C; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P. R. China.
Hou AJ; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.

Chem Biodivers ; 15(11): e1800426, 2018 Nov.

Article en En | MEDLINE | ID: mdl-30187609

RESUMEN

Two new triterpenoids, vistriterpenoids A (1) and B (2), and four known ones, were acquired from Dodonaea viscosa. Compounds 1 and 2 represent the 24-nor-oleanane triterpenoids isolated from the genus Dodonaea for the first time. Their structures were identified based on extensive spectroscopic methods. Compounds 1, 2, 5, and 6 exerted inhibitory activities against PTP1B inâvitro.

Asunto(s)

Inhibidores Enzimáticos/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Sapindaceae/química; Triterpenos/farmacología; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/aislamiento & purificación; Humanos; Conformación Molecular; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Relación Estructura-Actividad; Triterpenos/química; Triterpenos/aislamiento & purificación

Palabras clave

Dodonaea viscosa; PTP1B inhibitors; inhibitory activity; protein tyrosine phosphatase 1b (PTP1B); triterpenoids; vistriterpenoids A and B

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triterpenos / Sapindaceae / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article

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