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Rationally designed divalent caffeic amides inhibit amyloid-ß fibrillization, induce fibril dissociation, and ameliorate cytotoxicity.
Tu, Ling-Hsien; Tseng, Ning-Hsuan; Tsai, Ya-Ru; Lin, Tien-Wei; Lo, Yi-Wei; Charng, Jien-Lin; Hsu, Hua-Ting; Chen, Yu-Sheng; Chen, Rong-Jie; Wu, Ying-Ta; Chan, Yi-Tsu; Chen, Chang-Shi; Fang, Jim-Min; Chen, Yun-Ru.
Afiliación
  • Tu LH; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Tseng NH; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Tsai YR; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
  • Lin TW; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Lo YW; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Charng JL; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Hsu HT; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Chen YS; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
  • Chen RJ; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Wu YT; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
  • Chan YT; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
  • Chen CS; Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan.
  • Fang JM; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan; Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan. Electronic address: jmfang@ntu.edu.tw.
  • Chen YR; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan. Electronic address: yrchen@gate.sinica.edu.tw.
Eur J Med Chem ; 158: 393-404, 2018 Oct 05.
Article en En | MEDLINE | ID: mdl-30227353
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Ácidos Cafeicos / Péptidos beta-Amiloides Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Ácidos Cafeicos / Péptidos beta-Amiloides Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Taiwán