Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism <i>Thermogemmatispora</i> strain T81.

Xu, Buzhe; Aitken, Emma J; Baker, Benjamin P; Turner, Claire A; Harvey, Joanne E; Stott, Matthew B; Power, Jean F; Harris, Paul W R; Keyzers, Robert A; Brimble, Margaret A

Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism Thermogemmatispora strain T81.

Xu, Buzhe; Aitken, Emma J; Baker, Benjamin P; Turner, Claire A; Harvey, Joanne E; Stott, Matthew B; Power, Jean F; Harris, Paul W R; Keyzers, Robert A; Brimble, Margaret A.

Afiliación

Xu B; School of Chemical Sciences , 23 Symonds Street , Auckland 1010 , New Zealand . Email: m.brimble@auckland.ac.nz ; Tel: +64 9 9238259.
Aitken EJ; Maurice Wilkins Centre for Molecular Biodiscovery , The University of Auckland , Private Bag 92019 , Auckland 1142 , New Zealand . Email: rob.keyzers@vuw.ac.nz ; Tel: +64 4 4635117.
Baker BP; School of Chemical & Physical Sciences , The Centre for Biodiscovery , Victoria University of Wellington , PO Box 600 , Wellington 6140 , New Zealand.
Turner CA; School of Chemical & Physical Sciences , The Centre for Biodiscovery , Victoria University of Wellington , PO Box 600 , Wellington 6140 , New Zealand.
Harvey JE; School of Chemical & Physical Sciences , The Centre for Biodiscovery , Victoria University of Wellington , PO Box 600 , Wellington 6140 , New Zealand.
Stott MB; Maurice Wilkins Centre for Molecular Biodiscovery , The University of Auckland , Private Bag 92019 , Auckland 1142 , New Zealand . Email: rob.keyzers@vuw.ac.nz ; Tel: +64 4 4635117.
Power JF; School of Chemical & Physical Sciences , The Centre for Biodiscovery , Victoria University of Wellington , PO Box 600 , Wellington 6140 , New Zealand.
Harris PWR; School of Biological Sciences , University of Canterbury , Private Bag 4800 , Christchurch 8140 , New Zealand.
Keyzers RA; GNS Science , Private Bag 2000 , Taupo 3352 , New Zealand.
Brimble MA; GNS Science , Private Bag 2000 , Taupo 3352 , New Zealand.

Chem Sci ; 9(37): 7311-7317, 2018 Oct 07.

Article en En | MEDLINE | ID: mdl-30294420

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2018 Tipo del documento: Article

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2018 Tipo del documento: Article