A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress.

Okayama, Mikio; Kitabatake, Shotaro; Sato, Mariko; Fujimori, Kota; Ichikawa, Daiju; Matsushita, Maiko; Suto, Yutaka; Iwasaki, Genji; Yamada, Taketo; Kiuchi, Fumiyuki; Hirao, Maki; Kunieda, Hisako; Osada, Makoto; Okamoto, Shinichiro; Hattori, Yutaka

Okayama, Mikio; Kitabatake, Shotaro; Sato, Mariko; Fujimori, Kota; Ichikawa, Daiju; Matsushita, Maiko; Suto, Yutaka; Iwasaki, Genji; Yamada, Taketo; Kiuchi, Fumiyuki; Hirao, Maki; Kunieda, Hisako; Osada, Makoto; Okamoto, Shinichiro; Hattori, Yutaka.

Afiliación

Okayama M; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan; Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kitabatake S; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Sato M; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Fujimori K; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Ichikawa D; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Matsushita M; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Suto Y; Faculty of Pharmacy, Takasaki University of Health and Welfare, Gunma, Japan.
Iwasaki G; Faculty of Pharmacy, Takasaki University of Health and Welfare, Gunma, Japan.
Yamada T; Department of Pathology, Saitama Medical University, Saitama, Japan.
Kiuchi F; Division of Natural Medicines, Keio University Faculty of Pharmacy, Tokyo, Japan.
Hirao M; Department of Hematology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Kunieda H; Department of Hematology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Osada M; Department of Hematology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Okamoto S; Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Hattori Y; Clinical Physiology and Therapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan; Department of Hematology, Tokyo Saiseikai Central Hospital, Tokyo, Japan. Electronic address: hattori-yt@pha.keio.ac.jp.

Biochem Biophys Res Commun ; 505(3): 787-793, 2018 11 02.

Article en En | MEDLINE | ID: mdl-30297108

Asunto(s)

Apoptosis/efectos de los fármacos; Diterpenos/química; Estrés del Retículo Endoplásmico/efectos de los fármacos; Mieloma Múltiple/patología; Oxígeno/metabolismo; Quinonas/química; Animales; Línea Celular Tumoral; Diterpenos/farmacología; Factor 2 Eucariótico de Iniciación/metabolismo; Xenoinjertos; Humanos; Ratones; Mieloma Múltiple/tratamiento farmacológico; Fosforilación/efectos de los fármacos; Extractos Vegetales/química; Extractos Vegetales/farmacología; Extractos Vegetales/uso terapéutico; Quinonas/farmacología; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Apoptosis; ER stress; Multiple myeloma; Natural product; Reactive oxygen species

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxígeno / Quinonas / Apoptosis / Diterpenos / Estrés del Retículo Endoplásmico / Mieloma Múltiple Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: Japón

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