Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift.

Gutbier, Simon; May, Patrick; Berthelot, Sylvie; Krishna, Abhimanyu; Trefzer, Timo; Behbehani, Mehri; Efremova, Liudmila; Delp, Johannes; Gstraunthaler, Gerhard; Waldmann, Tanja; Leist, Marcel

Gutbier, Simon; May, Patrick; Berthelot, Sylvie; Krishna, Abhimanyu; Trefzer, Timo; Behbehani, Mehri; Efremova, Liudmila; Delp, Johannes; Gstraunthaler, Gerhard; Waldmann, Tanja; Leist, Marcel.

Afiliación

Gutbier S; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
May P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Berthelot S; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Krishna A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Trefzer T; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Behbehani M; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Efremova L; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Delp J; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Gstraunthaler G; Division of Physiology, Innsbruck Medical University, Schöpfstraße 41/1, 6020, Innsbruck, Austria.
Waldmann T; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.
Leist M; Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany. Marcel.Leist@uni-konstanz.de.

Arch Toxicol ; 92(12): 3487-3503, 2018 12.

Article en En | MEDLINE | ID: mdl-30298209

Asunto(s)

1-Metil-4-fenilpiridinio/toxicidad; Neuronas Dopaminérgicas/metabolismo; Flujo Genético; Secuenciación Completa del Genoma/métodos; Diferenciación Celular/efectos de los fármacos; Línea Celular; Células Cultivadas; Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/genética; Regulación hacia Abajo/genética; Humanos; Reproducibilidad de los Resultados; Tirosina 3-Monooxigenasa/genética

Palabras clave

Cell stability; Dopamine transporter, genome comparison, genotype-phenotype correlation; Human genome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: 1-Metil-4-fenilpiridinio / Flujo Genético / Neuronas Dopaminérgicas / Secuenciación Completa del Genoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Arch Toxicol Año: 2018 Tipo del documento: Article País de afiliación: Alemania

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