Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.
Int J Clin Oncol
; 24(4): 359-365, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30413914
ABSTRACT
BACKGROUND:
Emerging evidences were accumulated to support the view that GRP78 might be associated with multiple types of cancer. Given these, the aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) of GRP78 gene promoter and nasopharyngeal carcinoma (NPC).METHODS:
Three SNPs (rs3216733, rs17840761 and rs17840762) in GRR78 promoter were estimated in 422 NPC patients and 452 controls. Genotyping was performed using SNaPshot SNP. Serum GRP78 level was performed by enzyme-linked immunosorbent assay (ELISA). Data were analyzed by SPSS 17.0 software.RESULTS:
Significant association between rs3216733 polymorphism and NPC was observed (Cd vs. dd OR = 0.57, 95% CI 0.43-0.76, P < 0.001; CC vs. dd OR = 0.62, 95% CI 0.39-0.98, P = 0.043; Cd/CC vs. dd OR = 0.58, 95% CI 0.44-0.76, P < 0.001; C vs. d OR = 0.70, 95% CI 0.57-0.86, P = 0.001). Additionally, we further found that expression were down-regulated in serum of patients with NPC carrying rs3216733 CC genotype when compared to that of dd genotype (P < 0.001).CONCLUSION:
The observations suggest that rs3216733 polymorphism in the GRP78 gene promoter may correlate with NPC susceptibility.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Nasofaríngeas
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Polimorfismo de Nucleótido Simple
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Carcinoma Nasofaríngeo
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Proteínas de Choque Térmico
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Int J Clin Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2019
Tipo del documento:
Article
País de afiliación:
China