Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.

Chen, Miaomiao; Zhang, Hongqin; Zhang, Guihong; Zhong, Ailing; Ma, Qian; Kai, Jinyan; Tong, Yin; Xie, Suhong; Wang, Yanchun; Zheng, Hui; Guo, Lin; Lu, Renquan

Chen, Miaomiao; Zhang, Hongqin; Zhang, Guihong; Zhong, Ailing; Ma, Qian; Kai, Jinyan; Tong, Yin; Xie, Suhong; Wang, Yanchun; Zheng, Hui; Guo, Lin; Lu, Renquan.

Afiliación

Chen M; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang H; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang G; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Zhong A; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Ma Q; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Kai J; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Tong Y; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Xie S; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Wang Y; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Zheng H; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.
Guo L; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Lu R; Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: lurenquan@126.com.

Biochem Biophys Res Commun ; 507(1-4): 74-82, 2018 12 09.

Article en En | MEDLINE | ID: mdl-30454896

Asunto(s)

Apoptosis; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Proteínas de Ciclo Celular/metabolismo; Proteínas Asociadas a Microtúbulos/metabolismo; Proteínas Nucleares/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal; Proteína p53 Supresora de Tumor/metabolismo; Apoptosis/genética; Neoplasias de la Mama/genética; Línea Celular Tumoral; Movimiento Celular/genética; Proliferación Celular/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Bases de Datos Genéticas; Regulación hacia Abajo/genética; Femenino; Regulación Neoplásica de la Expresión Génica; Silenciador del Gen; Humanos; Persona de Mediana Edad; Ensayo de Tumor de Célula Madre

Palabras clave

AKT signaling pathway; Breast cancer; Cell apoptosis; TPX2; p53

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Nucleares / Transducción de Señal / Proteína p53 Supresora de Tumor / Apoptosis / Proteínas de Ciclo Celular / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Proteínas Asociadas a Microtúbulos Límite: Female / Humans / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google