Your browser doesn't support javascript.
loading
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Thomas, Michael G; De Rycker, Manu; Ajakane, Myriam; Albrecht, Sébastian; Álvarez-Pedraglio, Ana Isabel; Boesche, Markus; Brand, Stephen; Campbell, Lorna; Cantizani-Perez, Juan; Cleghorn, Laura A T; Copley, Royston C B; Crouch, Sabrinia D; Daugan, Alain; Drewes, Gerard; Ferrer, Santiago; Ghidelli-Disse, Sonja; Gonzalez, Silvia; Gresham, Stephanie L; Hill, Alan P; Hindley, Sean J; Lowe, Rhiannon M; MacKenzie, Claire J; MacLean, Lorna; Manthri, Sujatha; Martin, Franck; Miguel-Siles, Juan; Nguyen, Van Loc; Norval, Suzanne; Osuna-Cabello, Maria; Woodland, Andrew; Patterson, Stephen; Pena, Imanol; Quesada-Campos, Maria Teresa; Reid, Iain H; Revill, Charlotte; Riley, Jennifer; Ruiz-Gomez, Jose Ramon; Shishikura, Yoko; Simeons, Frederick R C; Smith, Alasdair; Smith, Victoria C; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Underwood, Tim; Gray, David W; Fiandor, Jose M; Gilbert, Ian H; Wyatt, Paul G.
Afiliación
  • Thomas MG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • De Rycker M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Ajakane M; Cellzome GmbH , A GlaxoSmithKline Company , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Albrecht S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Álvarez-Pedraglio AI; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Boesche M; Cellzome GmbH , A GlaxoSmithKline Company , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Brand S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Campbell L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Cantizani-Perez J; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Cleghorn LAT; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Copley RCB; Platform Technology & Science , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Crouch SD; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Daugan A; Centre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec , 91140 Villebon sur Yvette France.
  • Drewes G; Cellzome GmbH , A GlaxoSmithKline Company , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Ferrer S; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Ghidelli-Disse S; Cellzome GmbH , A GlaxoSmithKline Company , Meyerhofstrasse 1 , 69117 Heidelberg , Germany.
  • Gonzalez S; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Gresham SL; Platform Technology & Science , GlaxoSmithKline , David Jack Centre for R&D, Park Road , Ware , Hertfordshire SG12 0DP , U.K.
  • Hill AP; Platform Technology & Science , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Hindley SJ; Platform Technology & Science , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Lowe RM; Platform Technology & Science , GlaxoSmithKline , David Jack Centre for R&D, Park Road , Ware , Hertfordshire SG12 0DP , U.K.
  • MacKenzie CJ; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • MacLean L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Manthri S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Martin F; Centre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec , 91140 Villebon sur Yvette France.
  • Miguel-Siles J; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Nguyen VL; Centre de Recherche , GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec , 91140 Villebon sur Yvette France.
  • Norval S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Osuna-Cabello M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Woodland A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Patterson S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Pena I; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Quesada-Campos MT; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Reid IH; Platform Technology & Science , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Revill C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Ruiz-Gomez JR; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Shishikura Y; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Simeons FRC; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Smith A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Smith VC; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Spinks D; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Thomas J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Thompson S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Underwood T; Platform Technology & Science , GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Gray DW; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Fiandor JM; Global Health R&D , GlaxoSmithKline , Calle Severo Ochoa, 2 , 28760 Tres Cantos , Madrid Spain.
  • Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
  • Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee DD1 5EH , U.K.
J Med Chem ; 62(3): 1180-1202, 2019 02 14.
Article en En | MEDLINE | ID: mdl-30570265
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Tripanocidas / Morfolinas / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Tripanocidas / Morfolinas / Leishmaniasis Visceral Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido