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Encounter and React: Computer-Guided Design of Covalent Inhibitors.
Ung, Peter Man-Un; DeVita, Robert J; Schlessinger, Avner.
Afiliación
  • Ung PM; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • DeVita RJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Schlessinger A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: avner.schlessinger@mssm.edu.
Cell Chem Biol ; 26(1): 6-8, 2019 01 17.
Article en En | MEDLINE | ID: mdl-30658111
ABSTRACT
Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Proteínas Quinasas JNK Activadas por Mitógenos Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Proteínas Quinasas JNK Activadas por Mitógenos Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos