Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor <i>BIN1</i> does not affect amyloid pathology in an AD mouse model.

Andrew, Robert J; De Rossi, Pierre; Nguyen, Phuong; Kowalski, Haley R; Recupero, Aleksandra J; Guerbette, Thomas; Krause, Sofia V; Rice, Richard C; Laury-Kleintop, Lisa; Wagner, Steven L; Thinakaran, Gopal

Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.

Andrew, Robert J; De Rossi, Pierre; Nguyen, Phuong; Kowalski, Haley R; Recupero, Aleksandra J; Guerbette, Thomas; Krause, Sofia V; Rice, Richard C; Laury-Kleintop, Lisa; Wagner, Steven L; Thinakaran, Gopal.

Afiliación

Andrew RJ; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
De Rossi P; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Nguyen P; Department of Neurosciences, University of California, San Diego, La Jolla, California, 92093.
Kowalski HR; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Recupero AJ; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Guerbette T; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Krause SV; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Rice RC; From the Department of Neurobiology, The University of Chicago, Chicago, Illinois, 60637.
Laury-Kleintop L; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, 19096.
Wagner SL; Department of Neurosciences, University of California, San Diego, La Jolla, California, 92093.
Thinakaran G; Veterans Affairs San Diego Healthcare System, La Jolla, California, 92161.

J Biol Chem ; 294(12): 4477-4487, 2019 03 22.

Article en En | MEDLINE | ID: mdl-30692199

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales/genética; Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Predisposición Genética a la Enfermedad; Proteínas del Tejido Nervioso/genética; Proteínas Supresoras de Tumor/genética; Enfermedad de Alzheimer/genética; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Animales; Ácido Aspártico Endopeptidasas/metabolismo; Encéfalo/metabolismo; Modelos Animales de Enfermedad; Endocitosis; Endosomas/metabolismo; Femenino; Humanos; Masculino; Ratones; Ratones Noqueados

Palabras clave

5XFAD; APP; Alzheimer disease; BACE1; BIN1; GWAS; amphiphysin; amyloid; amyloid precursor protein (APP); beta-amyloid (AB); beta-secretase 1 (BACE1); endocytosis; neurodegeneration; pathogenesis; secretase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Precursor de Proteína beta-Amiloide / Predisposición Genética a la Enfermedad / Proteínas Supresoras de Tumor / Proteínas Adaptadoras Transductoras de Señales / Enfermedad de Alzheimer / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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