Loss of SMAD4 Promotes Colorectal Cancer Progression by Recruiting Tumor-Associated Neutrophils via the CXCL1/8-CXCR2 Axis.

Ogawa, Ryotaro; Yamamoto, Takamasa; Hirai, Hideyo; Hanada, Keita; Kiyasu, Yoshiyuki; Nishikawa, Gen; Mizuno, Rei; Inamoto, Susumu; Itatani, Yoshiro; Sakai, Yoshiharu; Kawada, Kenji

Ogawa, Ryotaro; Yamamoto, Takamasa; Hirai, Hideyo; Hanada, Keita; Kiyasu, Yoshiyuki; Nishikawa, Gen; Mizuno, Rei; Inamoto, Susumu; Itatani, Yoshiro; Sakai, Yoshiharu; Kawada, Kenji.

Afiliación

Ogawa R; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yamamoto T; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hirai H; Department of Transfusion Medicine and Cell Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hanada K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kiyasu Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nishikawa G; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Mizuno R; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Inamoto S; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Itatani Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sakai Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawada K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kkawada@kuhp.kyoto-u.ac.jp.

Clin Cancer Res ; 25(9): 2887-2899, 2019 05 01.

Article en En | MEDLINE | ID: mdl-30705034

Asunto(s)

Biomarcadores de Tumor/metabolismo; Quimiocina CXCL1/metabolismo; Neoplasias Colorrectales/patología; Interleucina-8/metabolismo; Neutrófilos/patología; Receptores de Interleucina-8B/metabolismo; Proteína Smad4/metabolismo; Apoptosis; Biomarcadores de Tumor/genética; Estudios de Casos y Controles; Movimiento Celular; Proliferación Celular; Quimiocina CXCL1/genética; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Progresión de la Enfermedad; Estudios de Seguimiento; Regulación Neoplásica de la Expresión Génica; Humanos; Interleucina-8/genética; Infiltración Neutrófila; Pronóstico; Receptores de Interleucina-8B/genética; Proteína Smad4/genética; Tasa de Supervivencia; Células Tumorales Cultivadas; Microambiente Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Interleucina-8 / Receptores de Interleucina-8B / Proteína Smad4 / Quimiocina CXCL1 / Neutrófilos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google