The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance <i>In Vitro</i> and Reduces Antibiotic Efficacy up to 100-Fold <i>In Vivo</i>.

Westfall, Corey; Flores-Mireles, Ana Lidia; Robinson, John Isaac; Lynch, Aaron J L; Hultgren, Scott; Henderson, Jeffrey P; Levin, Petra Anne

The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo.

Westfall, Corey; Flores-Mireles, Ana Lidia; Robinson, John Isaac; Lynch, Aaron J L; Hultgren, Scott; Henderson, Jeffrey P; Levin, Petra Anne.

Afiliación

Westfall C; Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
Flores-Mireles AL; Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
Robinson JI; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Lynch AJL; Division of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Hultgren S; Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
Henderson JP; Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA.
Levin PA; Division of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Antimicrob Agents Chemother ; 63(5)2019 05.

Article en En | MEDLINE | ID: mdl-30782996

Asunto(s)

Antiinfecciosos/uso terapéutico; Triclosán/uso terapéutico; Animales; Antiinfecciosos/economía; Antiinfecciosos/farmacocinética; Guanosina Tetrafosfato/metabolismo; Masculino; Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos; Staphylococcus aureus Resistente a Meticilina/patogenicidad; Ratones; Pruebas de Sensibilidad Microbiana; Triclosán/economía; Triclosán/farmacocinética; Infecciones Urinarias/tratamiento farmacológico; Infecciones Urinarias/metabolismo

Palabras clave

antimicrobial agents; antimicrobial safety; genetics; urinary tract infection

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triclosán / Antiinfecciosos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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